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Latest post-COVID research and innovation

Overview
Post-COVID lung damage research
Related research

Overview

Research publications and emerging studies   

In a matter of months our understanding of COVID-19 has moved at an astonishing rate and with the scale of COVID-19, we expect research insight on post-COVID to accumulate rapidly. We want to work with you to develop a clear strategy to advance our understanding, and facilitate knowledge sharing amongst the research community. It’s important that any approach to support people with lung damage is based on clear peer-reviewed evidence

We are focusing on two key areas of research:

– Post-COVID lung damage research

– Other research relevant to post-COVID breathlessness

Post-COVID lung damage research

Study	Citation
Pulmonary rehabilitation at a time of social distancing: prime time for tele-rehabilitation?	Thorax. 2020;75(6):446-447. doi:10.1136/thoraxjnl-2020-214788
Pulmonary rehabilitation for patients with coronavirus disease 2019 (COVID-19)	Chronic Dis Transl Med. 2020;10.1016/j.cdtm.2020.05.002. doi:10.1016/j.cdtm.2020.05.002
The Post-COVID-19 Functional Status (PCFS) Scale: a tool to measure functional status over time after COVID-19	European Respiratory Journal Jan 2020, 2001494; DOI: 10.1183/13993003.01494-2020
The British Thoracic Society survey of rehabilitation to support recovery of the Post Covid -19 population	medRxiv 2020.05.07.20094151; DOI: 10.1101/2020.05.07.20094151
COVID-19 ARDS: clinical features and differences to “usual” pre-COVID ARDS	Gibson PG, Qin L, Puah S. COVID-19 ARDS: clinical features and differences to “usual” pre-COVID ARDS. Med J Aust 2020; https://www.mja.com.au/journal/2020/covid-19-ards-clinical-features-and-differences-usual-pre-covid-ards [Preprint, 24 April 2020]
Urgent need of a management plan for survivors of COVID-19	European Respiratory Journal 2020 55: 2000764; DOI: 10.1183/13993003.00764-2020 Online ahead of print. April 23, 2020
The clinical dynamics of 18 cases of COVID-19 outside of Wuhan, China	European Respiratory Journal 2020 55: 2000398; DOI: 10.1183/13993003.00398-2020 Online ahead of print. April 23, 2020.
Pathogenesis of COVID-19 from a cell biology perspective	Eur Respir J. ;55(4):2000607. doi: 10.1183/13993003.00607-2020. Online ahead of print. 2020 Apr 16
Rehabilitation and Respiratory Management in the Acute and Early Post-Acute Phase. “Instant Paper From the Field” on Rehabilitation Answers to the Covid-19 Emergency	Eur J Phys Rehabil Med. 2020 Apr 15. doi: 10.23736/S1973-9087.20.06305-4. Online ahead of print. 2020 Apr 15
Rehabilitation After Critical Illness in People With COVID-19 Infection	Am J Phys Med Rehabil. 2020;99(6):470-474. doi:10.1097/PHM.0000000000001443
Coronavirus Disease 2019 (COVID-19) and Cardiovascular Disease: A Viewpoint on the Potential Influence of Angiotensin-Converting Enzyme Inhibitors/Angiotensin Receptor Blockers on Onset and Severity of Severe Acute Respiratory Syndrome Coronavirus 2 Infection	J Am Heart Assoc. 2020 Apr 7;9(7):e016219. doi: 10.1161/JAHA.120.016219. Online ahead of print. 2020 Apr 1
Respiratory rehabilitation in elderly patients with COVID-19: A randomized controlled study	Complement Ther Clin Pract. 2020 May; 39: 101166. doi: 10.1016/j.ctcp.2020.101166. Online ahead of print. 2020 Apr 1
High-resolution CT features of 17 cases of Corona Virus Disease 2019 in Sichuan province, China	Eur Respir J. 2020;2000334. doi:10.1183/13993003.00334-2020 [published online ahead of print, 2020 Mar 26].
The role of CT in case ascertainment and management of COVID-19 pneumonia in the UK: insights from high-incidence regions	Lancet Respir Med. 2020;S2213-2600(20)30132-6. doi:10.1016/S2213-2600(20)30132-6 [published online ahead of print, 2020 Mar 25].
Advances in the Research of Mechanism of Pulmonary Fibrosis Induced by Corona Virus Disease 2019 and the Corresponding Therapeutic Measures	Chinese journal of burns, vol. 36,0 E006. 16 Mar. 2020, doi:10.3760/cma.j.cn501120-20200307-00132
Coronavirus disease 2019: What we know?	J Med Virol. 2020;10.1002/jmv.25766. doi:10.1002/jmv.25766  [published online ahead of print, 2020 Mar 14].
Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China.	JAMA Intern Med. 2020;e200994. doi:10.1001/jamainternmed.2020.0994  [published online ahead of print, 2020 Mar 13].
Correlation of Chest CT and RT-PCR Testing in Coronavirus Disease 2019 (COVID-19) in China: A Report of 1014 Cases	Radiology. 2020;200642. doi:10.1148/radiol.2020200642 [published online ahead of print, 2020 Feb 26].
Understanding of COVID-19 based on current evidence	J Med Virol. 2020;10.1002/jmv.25722. doi:10.1002/jmv.25722 [published online ahead of print, 2020 Feb 25].
Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study	Lancet Respir Med. 2020 Feb 24. pii: S2213-2600(20)30079-5. doi: 10.1016/S2213-2600(20)30079-5. [Epub ahead of print]
Coronavirus Disease 2019 (COVID-19): A Perspective From China	Radiology. 2020;200490. doi:10.1148/radiol.2020200490 [published online ahead of print, 2020 Feb 21].
Pathological findings of COVID-19 associated with acute respiratory distress syndrome	Lancet Respir Med. 2020 Apr;8(4):420-422. doi: 10.1016/S2213-2600(20)30076-X. Online ahead of print. 2020 Feb 18.
Time Course of Lung Changes On Chest CT During Recovery From 2019 Novel Coronavirus (COVID-19) Pneumonia	Radiology.;200370. doi: 10.1148/radiol.2020200370. Online ahead of print. 2020 Feb 13
Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury	Sci China Life Sci. 2020; 63(3): 364-374. doi: 10.1007/s11427-020-1643-8. Online ahead of print. 2020 Feb 9.
Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China	JAMA. 2020;e201585. doi:10.1001/jama.2020.1585  [published online ahead of print, 2020 Feb 7].
Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study	Lancet. 2020;395(10223):507-513. doi:10.1016/S0140-6736(20)30211-7  Published Jan 30, 2020
Clinical Features of Patients Infected With 2019 Novel Coronavirus in Wuhan, China	Lancet. 2020;395(10223):497-506. doi:10.1016/S0140-6736(20)30183-5 [published correction appears in Lancet. 2020 Jan 30;:].

Related research

There may be much to learn from the impact of viral infections similar to COVID-19, and innovative approaches to meet a large, post-COVID demand for services to help people breathing difficulties.

The scale of COVID-19 is likely to mean a large demand for services breathing post-COVID. The following table encapsulates innovative research that may help guide a future research and innovation strategy.

Study	Citation
Neuropsychiatric outcome in subgroups of Intensive Care Unit survivors: Implications for after-care	J Crit Care. 2020 Feb;55:171-176. doi: 10.1016/j.jcrc.2019.11.006. Epub 2019 Nov 12.
Long-term bone and lung consequences associated with hospital-acquired severe acute respiratory syndrome: a 15-year follow-up from a prospective cohort study	Bone Res. 2020;8:8. Published 2020 Feb 14. doi:10.1038/s41413-020-0084-5
Viral Infection Increases the Risk of Idiopathic Pulmonary Fibrosis: A Meta-Analysis	Chest. 2019;S0012-3692(19)34200-X. doi:10.1016/j.chest.2019.10.032
Novel Risk Factors for Posttraumatic Stress Disorder Symptoms in Family Members of Acute Respiratory Distress Syndrome Survivors.	Crit Care Med. 2019 Jul;47(7):934-941. doi: 10.1097/CCM.0000000000003774.
Physical Function Trajectories in Survivors of Acute Respiratory Failure.	Ann Am Thorac Soc. 2019 Apr;16(4):471-477. doi: 10.1513/AnnalsATS.201806-375OC.
Anxiety, Depression and Post Traumatic Stress Disorder after critical illness: a UK-wide prospective cohort study.	Crit Care. 2018 Nov 23;22(1):310. doi: 10.1186/s13054-018-2223-6.
Co-Occurrence of Post-Intensive Care Syndrome Problems Among 406 Survivors of Critical Illness.	Crit Care Med. 2018 Sep;46(9):1393-1401. doi: 10.1097/CCM.0000000000003218.
The Role of Infection in Interstitial Lung Diseases	Chest. 2017;152(4):842-852. doi:10.1016/j.chest.2017.03.033
Interactive web-based pulmonary rehabilitation programme: a randomised controlled feasibility trial	Chaplin E, Hewitt S, Apps L, et alInteractive web-based pulmonary rehabilitation programme: a randomised controlled feasibility trialBMJ Open 2017;7:e013682. doi: 10.1136/bmjopen-2016-013682
Functional disability 5 years after acute respiratory distress syndrome	N Engl J Med. 2011 Apr 7;364(14):1293-304. doi: 10.1056/NEJMoa1011802.
Post-traumatic stress in the intensive care unit	Rev Bras Ter Intensiva. 2010 Mar;22(1):77-84.
Two-year cognitive, emotional, and quality-of-life outcomes in acute respiratory distress syndrome.	Am J Respir Crit Care Med. 2005 Feb 15;171(4):340-7. Epub 2004 Nov 12.