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Resource Hub

Latest post-COVID research and innovation

Overview
Post-COVID lung damage research
Related research

Overview

Latest post-COVID research – research publications and emerging studies   

In a matter of months our understanding of COVID-19 has moved at an astonishing rate and with the scale of COVID-19, we expect research insight on post-COVID to accumulate rapidly. We want to work with you to develop a clear strategy to advance our understanding, and facilitate knowledge sharing amongst the research community. It’s important that any approach to support people with lung damage is based on clear peer-reviewed evidence

We are focusing on two key areas of research:

Post-COVID lung damage research

Other research relevant to post-COVID breathlessness

We encourage you to get in touch, to share your research insights and ensure our lists are up-to-date.

Post-COVID lung damage research

StudyCitation
Pulmonary rehabilitation at a time of social distancing: prime time for tele-rehabilitation? Thorax. 2020;75(6):446‐447. doi:10.1136/thoraxjnl-2020-214788 
Pulmonary rehabilitation for patients with coronavirus disease 2019 (COVID-19) Chronic Dis Transl Med. 2020;10.1016/j.cdtm.2020.05.002. doi:10.1016/j.cdtm.2020.05.002 
The Post-COVID-19 Functional Status (PCFS) Scale: a tool to measure functional status over time after COVID-19 European Respiratory Journal Jan 2020, 2001494; DOI: 10.1183/13993003.01494-2020 
The British Thoracic Society survey of rehabilitation to support recovery of the Post Covid -19 population medRxiv 2020.05.07.20094151; DOI: 10.1101/2020.05.07.20094151 
COVID-19 ARDS: clinical features and differences to “usual” pre-COVID ARDS Gibson PG, Qin L, Puah S. COVID-19 ARDS: clinical features and differences to “usual” pre-COVID ARDS. Med J Aust 2020; https://www.mja.com.au/journal/2020/covid-19-ards-clinical-features-and-differences-usual-pre-covid-ards [Preprint, 24 April 2020] 
Urgent need of a management plan for survivors of COVID-19 European Respiratory Journal 2020 55: 2000764; DOI: 10.1183/13993003.00764-2020 Online ahead of print. April 23, 2020 
The clinical dynamics of 18 cases of COVID-19 outside of Wuhan, China European Respiratory Journal 2020 55: 2000398; DOI: 10.1183/13993003.00398-2020 Online ahead of print. April 23, 2020. 
Pathogenesis of COVID-19 from a cell biology perspective Eur Respir J. ;55(4):2000607. doi: 10.1183/13993003.00607-2020. Online ahead of print. 2020 Apr 16 
Rehabilitation and Respiratory Management in the Acute and Early Post-Acute Phase. “Instant Paper From the Field” on Rehabilitation Answers to the Covid-19 Emergency Eur J Phys Rehabil Med. 2020 Apr 15. doi: 10.23736/S1973-9087.20.06305-4. Online ahead of print. 2020 Apr 15 
Rehabilitation After Critical Illness in People With COVID-19 Infection Am J Phys Med Rehabil. 2020;99(6):470‐474. doi:10.1097/PHM.0000000000001443 
Coronavirus Disease 2019 (COVID‐19) and Cardiovascular Disease: A Viewpoint on the Potential Influence of Angiotensin‐Converting Enzyme Inhibitors/Angiotensin Receptor Blockers on Onset and Severity of Severe Acute Respiratory Syndrome Coronavirus 2 Infection J Am Heart Assoc. 2020 Apr 7;9(7):e016219. doi: 10.1161/JAHA.120.016219. Online ahead of print. 2020 Apr 1 
Respiratory rehabilitation in elderly patients with COVID-19: A randomized controlled study Complement Ther Clin Pract. 2020 May; 39: 101166. doi: 10.1016/j.ctcp.2020.101166. Online ahead of print. 2020 Apr 1 
High-resolution CT features of 17 cases of Corona Virus Disease 2019 in Sichuan province, China Eur Respir J. 2020;2000334. doi:10.1183/13993003.00334-2020 [published online ahead of print, 2020 Mar 26].  
The role of CT in case ascertainment and management of COVID-19 pneumonia in the UK: insights from high-incidence regions Lancet Respir Med. 2020;S2213-2600(20)30132-6. doi:10.1016/S2213-2600(20)30132-6 [published online ahead of print, 2020 Mar 25].  
Advances in the Research of Mechanism of Pulmonary Fibrosis Induced by Corona Virus Disease 2019 and the Corresponding Therapeutic Measures Chinese journal of burns, vol. 36,0 E006. 16 Mar. 2020, doi:10.3760/cma.j.cn501120-20200307-00132 
Coronavirus disease 2019: What we know? J Med Virol. 2020;10.1002/jmv.25766. doi:10.1002/jmv.25766  [published online ahead of print, 2020 Mar 14]. 
Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China. JAMA Intern Med. 2020;e200994. doi:10.1001/jamainternmed.2020.0994  [published online ahead of print, 2020 Mar 13]. 
Correlation of Chest CT and RT-PCR Testing in Coronavirus Disease 2019 (COVID-19) in China: A Report of 1014 Cases Radiology. 2020;200642. doi:10.1148/radiol.2020200642 [published online ahead of print, 2020 Feb 26].  
Understanding of COVID‐19 based on current evidence J Med Virol. 2020;10.1002/jmv.25722. doi:10.1002/jmv.25722 [published online ahead of print, 2020 Feb 25]. 
Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study Lancet Respir Med. 2020 Feb 24. pii: S2213-2600(20)30079-5. doi: 10.1016/S2213-2600(20)30079-5. [Epub ahead of print]  
 Coronavirus Disease 2019 (COVID-19): A Perspective From China Radiology. 2020;200490. doi:10.1148/radiol.2020200490 [published online ahead of print, 2020 Feb 21].  
Pathological findings of COVID-19 associated with acute respiratory distress syndrome Lancet Respir Med. 2020 Apr;8(4):420-422. doi: 10.1016/S2213-2600(20)30076-X. Online ahead of print. 2020 Feb 18. 
Time Course of Lung Changes On Chest CT During Recovery From 2019 Novel Coronavirus (COVID-19) Pneumonia Radiology.;200370. doi: 10.1148/radiol.2020200370. Online ahead of print. 2020 Feb 13 
Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury Sci China Life Sci. 2020; 63(3): 364–374. doi: 10.1007/s11427-020-1643-8. Online ahead of print. 2020 Feb 9.  
Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China JAMA. 2020;e201585. doi:10.1001/jama.2020.1585  [published online ahead of print, 2020 Feb 7]. 
Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Lancet. 2020;395(10223):507–513. doi:10.1016/S0140-6736(20)30211-7  Published Jan 30, 2020 
Clinical Features of Patients Infected With 2019 Novel Coronavirus in Wuhan, China Lancet. 2020;395(10223):497–506. doi:10.1016/S0140-6736(20)30183-5 [published correction appears in Lancet. 2020 Jan 30;:].  

Related research

There may be much to learn from the impact of viral infections similar to COVID-19, and innovative approaches to meet a large, post-COVID demand for services to help people breathing difficulties.

The scale of COVID-19 is likely to mean a large demand for services breathing post-COVID. The following table encapsulates innovative research that may help guide a future research and innovation strategy.

StudyCitation
Neuropsychiatric outcome in subgroups of Intensive Care Unit survivors: Implications for after-careJ Crit Care. 2020 Feb;55:171-176. doi: 10.1016/j.jcrc.2019.11.006. Epub 2019 Nov 12.
Long-term bone and lung consequences associated with hospital-acquired severe acute respiratory syndrome: a 15-year follow-up from a prospective cohort studyBone Res. 2020;8:8. Published 2020 Feb 14. doi:10.1038/s41413-020-0084-5
Viral Infection Increases the Risk of Idiopathic Pulmonary Fibrosis: A Meta-AnalysisChest. 2019;S0012-3692(19)34200-X. doi:10.1016/j.chest.2019.10.032
Novel Risk Factors for Posttraumatic Stress Disorder Symptoms in Family Members of Acute Respiratory Distress Syndrome Survivors.Crit Care Med. 2019 Jul;47(7):934-941. doi: 10.1097/CCM.0000000000003774.
Physical Function Trajectories in Survivors of Acute Respiratory Failure.Ann Am Thorac Soc. 2019 Apr;16(4):471-477. doi: 10.1513/AnnalsATS.201806-375OC.
Anxiety, Depression and Post Traumatic Stress Disorder after critical illness: a UK-wide prospective cohort study.Crit Care. 2018 Nov 23;22(1):310. doi: 10.1186/s13054-018-2223-6.
Co-Occurrence of Post-Intensive Care Syndrome Problems Among 406 Survivors of Critical Illness.Crit Care Med. 2018 Sep;46(9):1393-1401. doi: 10.1097/CCM.0000000000003218.
The Role of Infection in Interstitial Lung DiseasesChest. 2017;152(4):842–852. doi:10.1016/j.chest.2017.03.033
Interactive web-based pulmonary rehabilitation programme: a randomised controlled feasibility trialChaplin E, Hewitt S, Apps L, et alInteractive web-based pulmonary rehabilitation programme: a randomised controlled feasibility trialBMJ Open 2017;7:e013682. doi: 10.1136/bmjopen-2016-013682
Functional disability 5 years after acute respiratory distress syndromeN Engl J Med. 2011 Apr 7;364(14):1293-304. doi: 10.1056/NEJMoa1011802.
Post-traumatic stress in the intensive care unitRev Bras Ter Intensiva. 2010 Mar;22(1):77-84.
Two-year cognitive, emotional, and quality-of-life outcomes in acute respiratory distress syndrome.Am J Respir Crit Care Med. 2005 Feb 15;171(4):340-7. Epub 2004 Nov 12.

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